Related Experiment Video
Updated: Feb 6, 2026

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
Published on: May 4, 2011
Observation of Singlet Oxygen with Single-Molecule Photosensitization by Time-Dependent Photon Statistics
Yao Li1,2, Ruiyun Chen1,2, Haitao Zhou1,2
1State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Laser Spectroscopy , Shanxi University , Taiyuan 030006 , China.
Abstract:
The singlet oxygen has been widely applied to the treatment of physiological diseases, and the photosensitized generation of singlet oxygen is the main means of its physiological applications. On the basis of the fluctuation of fluorescence field from single photosensitizer, we characterize the generation of singlet oxygen at single molecule level with the time-dependent photon statistical method. By measuring the time-tagged-time-resolved single-molecule fluorescence photons, we analyze the time-dependent Mandel-Q parameter, which has been performed at different oxygen environment. It is shown that the single molecule not only offers an efficient way of generating singlet oxygen in ambient condition but also provides insights for the fluctuation of singlet oxygen in the nanoscale environment. The method of time-dependent photon statistics provides a convenient methodology for observing photosensitizers generating singlet oxygen in real time at single photosensitizer level.
Related Concept Videos
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Statistical Significance
The Integrated Rate Law: The Dependence of Concentration on Time
Molecules and Compounds
Probability in Statistics
An example of a simple event is a coin toss. The result of a coin toss is either a head or a tail. Here, head and tail are two simple events. These two simple events make up the sample space. Further, the probability of an event occurring falls within the range of 0 to 1. The probability of an...
Introduction to Statistics
In statistics, the collection of individuals or objects under study is called population. The idea of sampling is to select a portion of the larger population...

