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Updated: Feb 6, 2026

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer
Published on: March 24, 2013
Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment
Leonardo A Moraes1, Patrick B Ampomah1, Lina H K Lim1
1a Department of Physiology , Yong Loo Lin School of Medicine, National University of Singapore, & NUS Immunology Program, Life Sciences Institute, Centre for Life Sciences, National University of Singapore , Singapore.
Abstract:
Targeting inflammation in cancer has shown promise to improve and complement current therapies. The tumor microenvironment plays an important role in cancer growth and metastasis and -tumor associated macrophages possess pro-tumoral and pro-metastatic properties. Annexin A1 (ANXA1) is an immune-modulating protein with diverse functions in the immune system and in cancer. In breast cancer, high ANXA1 expression leads to poor prognosis and increased metastasis. Here, we will review ANXA1 as a modulator of inflammation, and discuss its importance in breast cancer and highlight its new role in alternative macrophage activation in the tumor microenvironment. This review may provide an updated understanding into the various roles of ANXA1 which may enable future therapeutic developments for the treatment of breast cancer.
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