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Epilepsy and Seizures: Overview01:24

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Brain tumor related-epilepsy.

Eric D Goldstein1, Anteneh M Feyissa1

  • 1Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.

Neurologia I Neurochirurgia Polska
|August 21, 2018
PubMed
Summary
This summary is machine-generated.

Brain tumor-related epilepsy (BTRE) complicates glioma treatment. Understanding epileptogenesis mechanisms and molecular markers is key to developing targeted therapies and personalized medicine for glioma patients.

Keywords:
Antiepileptic drugsEpileptogensisGliomaIDH1 mutationTumors markers

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Area of Science:

  • Neuro-oncology
  • Epileptology
  • Molecular Genetics

Background:

  • Gliomas frequently cause epilepsy, with shared pathogenic mechanisms influencing both conditions.
  • Brain tumor-related epilepsy (BTRE) significantly complicates glioma management and patient quality of life.
  • While tumor location and grade were previously emphasized, molecular genetic markers are increasingly linked to epileptogenesis in gliomas.

Purpose of the Study:

  • To elucidate the complex relationship between gliomas and epilepsy.
  • To identify key mechanisms driving epileptogenesis in the context of glioma.
  • To explore novel therapeutic targets for treating both glioma and associated epilepsy.

Main Methods:

  • Review of current literature on glioma-associated epilepsy.
  • Analysis of molecular genetic markers implicated in epileptogenesis.
  • Examination of established and emerging treatment modalities for BTRE.

Main Results:

  • Glutamate-induced excitotoxicity and disrupted intracellular communication are primary suspected mechanisms of epileptogenesis.
  • Tumor molecular markers, rather than grade or location, appear more significantly associated with seizure development.
  • A multidisciplinary approach including antiepileptic drugs (AEDs), surgery, and chemoradiation is standard for BTRE management.

Conclusions:

  • Further research into glioma growth and epileptogenesis mechanisms is crucial for identifying new therapeutic targets.
  • Developing AEDs that target specific molecular markers involved in epileptogenesis holds promise for personalized BTRE treatment.
  • Individualized medicine approaches for BTRE can enhance treatment efficacy by tailoring therapies to molecular profiles.