Related Experiment Video
Updated: Feb 6, 2026
15:03
Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
Published on: July 4, 2007
11.4K
Opportunities for Host-targeted Therapies for Malaria
Elizabeth K K Glennon1, Selasi Dankwa2, Joseph D Smith3
1Center for Infectious Disease Research, 307 Westlake Ave N Suite 500, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Harris Hydraulics Laboratory, Box 357965, Seattle, WA 98195, USA; These authors made an equal contribution.
Trends in Parasitology
|August 21, 2018
Summary
New host-targeted therapies offer hope against malaria, addressing limitations of current drugs. This approach could combat severe malaria and target elusive parasite stages, aiding global eradication efforts.
Area of Science:
- Infectious disease research
- Drug development
- Parasitology
Background:
- Artemisinin-based antimalarial drugs have shown success, but severe malaria persists.
- Current antimalarials are limited in targeting transmissible gametocytes and dormant Plasmodium vivax hypnozoites.
- Host-targeted therapy presents a novel strategy for infectious disease treatment.
Purpose of the Study:
- To explore new opportunities for host-targeted therapeutics against Plasmodium infection.
- To discuss the potential of drug polypharmacology for malaria treatment.
- To review advances in understanding host pathways in malaria pathogenesis.
Main Methods:
- Review of recent scientific literature on host-targeted therapy for malaria.
- Analysis of host pathways involved in Plasmodium parasite development.
- Exploration of drug polypharmacology for targeting multiple host pathways.
Main Results:
- Identification of new avenues for developing host-targeted interventions against malaria.
- Potential for single drug interventions to target multiple host pathways.
- Advances in understanding host-parasite interactions offer therapeutic possibilities.
Conclusions:
- Host-targeted therapies represent a promising new direction for malaria drug development.
- Harnessing polypharmacology can lead to more effective single-drug treatments.
- Interfering with host pathways could overcome limitations of current antimalarial drugs and aid eradication.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.9K
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
01:26Group Therapy
450
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
450
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
01:22Behavior Therapy
726
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
726
01:28Drug Therapy
301
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
301