Pharmaceutical considerations with conjoined twins
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Published on: January 27, 2021
Emily Rodman1, Jennifer L Placencia2
1Clinical Pharmacy Specialist - Neonatology and Obstetrics; Texas Children's Hospital, Baylor College of Medicine.
Abstract:
Sharing of the vascular system in conjoined twins creates pharmaceutical dilemmas that require individualization of protocols. One of the major goals for the medical team is to determine how medications should be administered, dosed, and monitored in each set of conjoined twins. In order to achieve these goals, the team must determine the extent of shared circulation, volume of distribution, effectiveness of enteral absorption, renal clearance, and develop processes to ensure medication safety. In this article, we discuss unique challenges in medication practices in conjoined twins and present general principles that can be applied to determine optimal pharmaceutical strategies.
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