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New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

Simona Sestito1, Massimiliano Runfola1, Marco Tonelli2

  • 1Department of Pharmacy, University of Pisa, Pisa, Italy.

Frontiers in Pharmacology
|August 21, 2018
PubMed

Insights

Glioblastoma multiforme (GBM) is a deadly brain cancer. Multi-targeted therapies show promise against GBM, overcoming resistance seen with single-drug treatments like Temozolomide (TMZ).

Area of Science:

  • Neuro-oncology
  • Cancer Therapeutics
  • Molecular Biology

Background:

  • Glioblastoma multiforme (GBM) is the most prevalent and lethal primary brain tumor.
  • Current treatments (surgery, radiation, chemotherapy) offer limited efficacy and survival rates.
  • Drug resistance, particularly to Temozolomide (TMZ), necessitates novel therapeutic strategies.

Purpose of the Study:

  • To review innovative preclinical strategies for Glioblastoma multiforme (GBM) treatment.
  • To highlight the potential of multi-targeted therapeutic approaches in overcoming GBM resistance.
  • To discuss advancements in anticancer drug discovery for brain tumors.

Main Methods:

  • Review of recent preclinical research in GBM therapy.
  • Focus on multi-targeted strategies inhibiting multiple molecular pathways.
  • Analysis of drug resistance mechanisms and combination therapies.

Main Results:

  • Single-agent therapies like Temozolomide (TMZ) frequently lead to drug resistance and relapse.
  • Multi-targeted approaches demonstrate potential for enhanced efficacy in preclinical models.
  • Combination therapies targeting multiple molecular nodes offer a promising alternative to monotherapy.

Conclusions:

  • A multi-targeted therapeutic strategy is a promising avenue for overcoming Glioblastoma multiforme (GBM) resistance.
  • Innovative preclinical research is crucial for developing more effective brain cancer treatments.
  • Targeting multiple molecular pathways represents a significant advancement in Glioblastoma multiforme (GBM) drug discovery.
Keywords:
combination therapyglioblastomamultiple kinase inhibitormultitarget drugsmall molecules

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