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The clinical prognostic significance of hs-cTnT elevation in patients with acute ischemic stroke

Lanying He1, Jian Wang2, Weiwei Dong3

  • 1Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, 400010, People's Republic of China. 531324679@qq.com.

BMC Neurology
|August 21, 2018
PubMed

Insights

Elevated high sensitivity cardiac troponin (hs-cTnT) levels in acute ischemic stroke patients are linked to a higher risk of death or major disability. This finding suggests hs-cTnT can help predict poor outcomes after stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Ischemic stroke can cause cardiac autonomic dysfunction, potentially leading to adverse outcomes.
  • Elevated high sensitivity cardiac troponin (hs-cTnT) is a cardiac disease marker that can be present in acute stroke patients.

Purpose of the Study:

  • To investigate the association between serum hs-cTnT levels and prognosis in patients with acute ischemic stroke.

Main Methods:

  • A cohort of 516 acute ischemic stroke patients underwent clinical investigation and serum hs-cTnT testing.
  • Patients were followed up for 3 months to assess prognosis, defined as death or major disability (modified Rankin Scale score ≥ 3).

Main Results:

  • Serum hs-cTnT elevation (≥14 ng/l) was observed in 22.87% of patients.
  • Patients with hs-cTnT elevation had a higher incidence of insular stroke.
  • Elevated hs-cTnT was independently associated with increased risk of death (aOR 3.14), major disability (aOR 2.07), and composite outcomes (aOR 2.22).

Conclusions:

  • Higher serum hs-cTnT levels are independently associated with an increased risk of death or major disability following ischemic stroke.
  • Serum hs-cTnT may serve as a valuable prognostic biomarker for predicting poor outcomes in ischemic stroke patients.
Abstract

Keywords:
Acute ischemic strokeHeart damageHs-cTnT,electrocardiographic abnormalityInsular stroke

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