Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

766
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
766
Inflammatory Response01:28

Inflammatory Response

16.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.9K
Wave Parameters01:10

Wave Parameters

9.4K
The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peter Dyck, MD (1927-2025).

Neurology·2026
Same author

A Rare Biopsy-Confirmed Case of Wild-Type Transthyretin Amyloid Polyneuropathy and Autonomic Neuropathy.

Muscle & nerve·2026
Same author

Sensitivity of Nerve and Skin Biopsy and Fat Aspirate for Amyloid in Symptomatic Hereditary ATTR Amyloidosis With Peripheral Neuropathy.

Neurology·2026
Same author

Perineural spread of colorectal carcinoma into the sciatic nerve with positive circulating tumor DNA test: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Clinical Insights Into CASPR1 and CASPR1/Contactin-1 Complex Autoimmune Nodopathies.

Neurology·2026
Same author

Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy.

EBioMedicine·2025

Related Experiment Video

Updated: Feb 6, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.3K

Inflammatory Diabetic Neuropathy: Helpful Diagnostic Parameters.

Pariwat Thaisetthawatkul1, J Americo Fernandes1,2, Ezequiel Piccione1

  • 1Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE.

Journal of Clinical Neuromuscular Disease
|August 21, 2018
PubMed
Summary

Inflammatory diabetic neuropathies (IDN) present with limb weakness and severe nerve damage, differing from diabetic sensorimotor neuropathy (DPN). Nerve biopsy and immunotherapy response can help distinguish IDN, offering treatment insights.

More Related Videos

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.4K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

409

Related Experiment Videos

Last Updated: Feb 6, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.3K
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.4K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

409

Area of Science:

  • Neurology
  • Immunology
  • Diabetology

Background:

  • Diabetic neuropathies (DPN) are common, but mild inflammatory diabetic neuropathies (IDN) share overlapping clinical and diagnostic features.
  • Differentiating IDN from DPN is crucial for appropriate management and treatment strategies.

Purpose of the Study:

  • To determine if clinical, electrophysiological, pathological, or laboratory tests can differentiate inflammatory diabetic neuropathies (IDN) from diabetic sensorimotor neuropathy (DPN).

Main Methods:

  • Suspected IDN cases were identified based on subacute onset and progressive sensory or motor neuropathy in diabetic patients.
  • Clinical features, electrophysiological tests, nerve biopsies, and laboratory findings were analyzed to compare IDN and DPN.

Main Results:

  • Inflammatory diabetic neuropathies (IDN) occurred earlier in diabetes mellitus, presenting with limb weakness, walking difficulty, and more severe electrophysiological abnormalities (demyelination and axonal loss).
  • Nerve biopsies in IDN revealed perivascular inflammatory infiltrates, reduced fiber density, increased demyelination, and axonal degeneration.
  • A significant majority of IDN patients showed improvement following immunotherapy.

Conclusions:

  • Limb weakness, pronounced nerve conduction abnormalities, inflammatory infiltrates on biopsy, and positive response to immunotherapy are key indicators favoring IDN over DPN.
  • Nerve biopsy is a valuable diagnostic tool for confirming an inflammatory etiology in diabetic neuropathy.
  • These findings aid in distinguishing IDN from DPN, guiding targeted therapeutic interventions.