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Targeted Cancer Therapies

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Related Experiment Video

Updated: Jan 19, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

Aptamer-based targeted therapy.

Guizhi Zhu¹, Xiaoyuan Chen²

¹Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.

Advanced Drug Delivery Reviews

|August 21, 2018

Summary

This summary is machine-generated.

Nucleic acid aptamers offer precise targeting for diseases by binding to biomarkers. Aptamer therapeutics and aptamer-drug conjugates show promise for advanced precision medicine applications.

Keywords:

Aptamer Aptamer-drug conjugate Drug delivery Nucleic acid therapeutics Targeted immunotherapy

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Last Updated: Jan 19, 2026

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

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Primer-Free Aptamer Selection Using A Random DNA Library

Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

Area of Science:

Biomedical Sciences
Molecular Biology
Genomics

Background:

Precision medicine leverages genetic and epigenetic information for targeted disease treatment.
Proteomic profiles offer accessible molecular targets for disease diagnosis, prognosis, and therapy.
Aptamers, DNA or RNA molecules with specific 3D structures, bind to disease biomarkers.

Purpose of the Study:

To review recent advancements in aptamer-based targeted therapy.
To discuss challenges and opportunities in aptamer therapeutics and aptamer-drug conjugates (ApDCs).

Main Methods:

Aptamers are screened for specific binding to target molecules.
Chemical modifications enhance aptamer stability, bioavailability, and therapeutic potential.
Aptamer-drug conjugates (ApDCs) are explored for enhanced drug delivery.

Main Results:

Aptamers demonstrate high specificity and affinity for disease biomarkers.
Chemically modified aptamers exhibit improved resistance to degradation and optimized pharmacokinetics.
Aptamer-based strategies are advancing targeted therapy for various diseases.

Conclusions:

Aptamers are versatile tools for precision medicine, enabling targeted diagnosis and therapy.
Further research into aptamer therapeutics and ApDCs can overcome current challenges.
Aptamer technology holds significant potential for developing novel treatments for complex diseases.