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Psychosis and synthetic cannabinoids.

Huiqiong Deng1, Christopher D Verrico2, Thomas R Kosten2

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Summary

Synthetic cannabinoids (SCs) are potent drugs that can induce psychotic symptoms, including new-onset psychosis and relapses. Their complex effects on psychosis go beyond those of natural cannabis.

Keywords:
CannabinoidsCannabisK2Psychoactive substancesPsychosisSpiceSynthetic cannabinoids

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Area of Science:

  • Psychiatry
  • Toxicology
  • Pharmacology

Background:

  • Synthetic cannabinoids (SCs) are increasingly prevalent abused drugs with wide-ranging psychological and physiological effects.
  • These substances have been linked to adverse mental health outcomes, including mood disturbances and psychosis.

Purpose of the Study:

  • To review the effects of synthetic cannabinoids on psychotic symptoms in clinical settings.
  • To explore the chemistry and mechanisms of action potentially underlying SC-induced psychosis.

Main Methods:

  • Literature review focusing on clinical reports and scientific studies concerning synthetic cannabinoids and psychosis.
  • Analysis of chemical properties and proposed mechanisms of action for SCs.

Main Results:

  • Consumption of SC products has been associated with the induction of psychotic symptoms, such as new-onset psychosis and psychotic relapses.
  • The impact of SCs on psychosis is complex and may not be directly comparable to the effects of natural cannabinoids.

Conclusions:

  • Synthetic cannabinoids pose a significant risk for inducing or exacerbating psychotic symptoms.
  • Understanding the intricate chemistry and pharmacology of SCs is crucial for managing their adverse psychiatric effects.