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Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation

Esther S Bochmann1, Andreas Gryczke2, Karl G Wagner3

  • 1Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, 53121 Bonn, Germany. esther.bochmann@uni-bonn.de.

Pharmaceutics
|August 22, 2018
PubMed
Summary

Model-based melt viscosity accurately simulates amorphous solid dispersions (ASDs) in hot-melt extrusion (HME). This approach reduces computational complexity without compromising simulation accuracy for pharmaceutical development.

Keywords:
amorphous solid dispersionglass transition temperaturehot-melt extrusionmelt rheologyprediction modelsimulation

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