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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.8K

Circular RNA: new star, new hope in cancer

Zikang Zhang1, Qing Xie1, Dongmei He2

  • 1Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Guangdong Medical University, Dongguan, 523808, China.

BMC Cancer
|August 22, 2018
PubMed
Abstract

Insights

Circular RNAs (ribonucleic acids) are key regulators in cancer, influencing tumor growth. Their stability and detectability make them promising biomarkers for cancer diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs regulating cellular processes.
  • Diverse circRNAs with varying cytogenetics are implicated in cancer development.
  • circRNAs can act as tumor inhibitors or accelerators via mechanisms like microRNA sponging.

Purpose of the Study:

  • To summarize recent advances in understanding circRNAs in cancer.
  • To describe a circRNA network associated with tumorigenesis.
  • To discuss the clinical implications of circRNAs in oncology.

Main Methods:

  • Literature review of recent advances in circRNA research in cancer.
  • Analysis of circRNA regulatory networks involved in tumorigenesis.
  • Discussion of clinical applications and biomarker potential of circRNAs.

Main Results:

  • circRNAs play crucial regulatory roles in various cancers.
  • A circRNA network associated with tumorigenesis has been identified.
  • circRNAs demonstrate potential as novel cancer biomarkers.

Conclusions:

  • Elucidating circRNA functional mechanisms is key to building circRNA-miRNA-mRNA regulatory networks.
  • circRNAs are stable, widely expressed, and abundant in biofluids (exosomes, blood, saliva).
  • circRNAs hold significant potential as ideal clinical biomarkers for cancer detection and management.
Keywords:
CancerCircular RNAClinical implicationExosomeMicroRNA spongeRegulation network

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