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Related Experiment Video

Updated: Feb 6, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

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Real-world experience comparing two common left atrial appendage closure devices.

Christian Fastner1, Lea Hoffmann2, Mohamed Aboukoura2

  • 1First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Centre for AngioScience (ECAS), and DZHK (German Centre for Cardiovascular Research) partner site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. christian.fastner@umm.de.

BMC Cardiovascular Disorders
|August 22, 2018
PubMed
Summary

Left atrial appendage closure (LAAC) offers an alternative to oral anticoagulation for non-valvular atrial fibrillation patients. This study found both Watchman™ and Amplatzer™ Amulet™ devices demonstrated high procedural success with rare, evenly distributed complications.

Keywords:
Atrial fibrillationComparisonLeft atrial appendageLeft atrial appendage closure deviceOutcome

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Left atrial appendage closure (LAAC) is a guideline-recommended alternative to oral anticoagulation (OAC) for patients with non-valvular atrial fibrillation who are ineligible for OAC.
  • This study directly compares the real-world performance of two contemporary LAAC devices.

Purpose of the Study:

  • To directly compare the safety and efficacy of two contemporary left atrial appendage closure devices in a real-world patient population.
  • To evaluate procedural success rates and complication profiles of Watchman™ and Amplatzer™ Amulet™ devices.

Main Methods:

  • A retrospective analysis of 189 patients undergoing LAAC between 2010 and 2017 across two centers.
  • Patients received either a Watchman™ device (n=148) or an Amplatzer™ Amulet™ device (n=34).
  • Data collected included baseline characteristics, procedural details, and in-hospital and 6-month follow-up event rates.

Main Results:

  • Both devices achieved high successful implantation rates (Watchman™: 96.1%, Amplatzer™ Amulet™: 97.1%).
  • Major access site bleedings were significantly more frequent with the Amplatzer™ Amulet™ device (8.9% vs. 1.4%, p=0.046).
  • No in-hospital thromboembolic events occurred; peri-device leaks and thromboembolic events at 6-month follow-up were uncommon and similar between groups.

Conclusions:

  • Both contemporary LAAC devices, Watchman™ and Amplatzer™ Amulet™, demonstrate high procedural success rates.
  • Complications during follow-up were rare and comparable between the two devices, suggesting similar long-term safety profiles.