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Isolation and Transplantation of Hematopoietic Stem Cells HSCs
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Peripheral T-cell Lymphomas: Updates in Allogeneic Hematopoietic Stem Cell Transplantation
Wen-Rong Huang1, Dai-Hong Liu1
1Department of Hematology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Chinese Medical Journal
|August 22, 2018
Summary
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers a promising treatment for Peripheral T-cell Lymphomas (PTCLs). Advances in transplant technology are improving outcomes for patients with poor prognosis PTCLs.
Area of Science:
- Hematology
- Oncology
- Transplantation Science
Background:
- Peripheral T-cell Lymphomas (PTCLs) present a poor prognosis.
- The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in PTCLs remains debated due to rarity and heterogeneity.
Purpose of the Study:
- To review critical aspects of allo-HSCT for PTCLs.
- Key points include indications, timing, conditioning, graft-versus-host disease (GVHD) prophylaxis, and relapse management.
Main Methods:
- A comprehensive literature search was conducted in PubMed and Cochrane databases.
- Keywords included "Peripheral", "T", "Lymphoma", and "Transplantation" up to February 28, 2018.
- Relevant articles on HSCT for PTCLs were systematically reviewed.
Main Results:
- Advances in transplant technology have yielded promising outcomes.
- An increasing number of PTCLs patients with poor prognosis are benefiting from allo-HSCT.
Conclusions:
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a viable option for PTCLs.
- It is particularly useful for refractory/relapsed PTCLs and high-risk newly diagnosed PTCLs.
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