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Updated: Feb 6, 2026
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PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
Published on: December 28, 2017
10.1K
Second Re-irradiation: Clinical Examples of Worthwhile Treatment
Carsten Nieder1, Rosalba Yobuta2, Bård Mannsåker1
1Oncology and Palliative Medicine, Nordland Hospital Trust, Bodø, NOR.
Cureus
|August 22, 2018
Summary
Second re-irradiation offers palliative benefits for incurable cancer patients, providing symptom relief without significant late side effects. This repeat radiotherapy option can improve quality of life and prolong independent living.
Area of Science:
- Oncology
- Radiation Oncology
- Palliative Care
Background:
- Advanced cancer treatments improve survival but necessitate ongoing symptom management.
- Re-irradiation is a crucial option for palliative care in incurable cancers.
- Limited data exists on the safety and efficacy of second re-irradiation.
Purpose of the Study:
- To evaluate the outcomes of second re-irradiation in patients with incurable cancer.
- To assess the palliative effects and toxicity of repeat radiotherapy.
- To provide illustrative clinical examples of second re-irradiation.
Main Methods:
- Retrospective analysis of a single institution database.
- Identification of patients receiving second re-irradiation with cumulative EQD2 > 90 Gy and survival > 6 months.
- Case examples of sacral bone metastases, recurrent rectal cancer, and pelvic lymph node metastases.
Main Results:
- Second re-irradiation achieved symptomatic responses in treated cases.
- Maximum cumulative EQD2 reached 142 Gy.
- No clinically relevant late side effects were observed.
Conclusions:
- Second re-irradiation can provide significant palliative benefits in select incurable cancer patients.
- It offers a viable option for symptom control without substantial late toxicity.
- This approach may enhance quality of life and prolong independent living for patients with incurable cancer.
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