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Trends in herbgenomics.

Tianyi Xin1, Yu Zhang1, Xiangdong Pu1

  • 1Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100193, China.

Science China. Life Sciences
|August 22, 2018
PubMed
Summary

Herbgenomics integrates traditional Chinese medicine (TCM) with advanced omics studies to uncover the genetic basis of herbs. This approach clarifies molecular mechanisms for disease prevention and treatment, modernizing TCM.

Keywords:
herbgenomics (bencaogenomics)omicspractical applicationtraditional Chinese medicine

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Area of Science:

  • Integrative Medicine
  • Genomics
  • Pharmacology

Background:

  • Traditional Chinese Medicine (TCM) has a long history, with milestones involving screening, testing, and integration.
  • Herbgenomics (bencaogenomics) bridges TCM with advanced omics studies, incorporating frontier technologies.

Purpose of the Study:

  • To introduce herbgenomics as a discipline for understanding the genetic information and regulatory networks of medicinal herbs.
  • To clarify the molecular mechanisms of herbs in disease prevention and treatment.

Main Methods:

  • Genomics
  • Functional genomics
  • Proteomics
  • Transcriptomics
  • Metabolomics
  • Epigenomics
  • Metagenomics
  • Synthetic biology
  • Pharmacogenomics of TCM
  • Bioinformatics

Main Results:

  • Herbgenomics provides a theoretical system integrating multiple omics fields.
  • It enables the study of medicinal model plants and genomic-assisted breeding.
  • Applications include herbal synthetic biology, gene resource management, TCM quality control, and drug development.

Conclusions:

  • Herbgenomics accelerates the application of cutting-edge technologies in TCM research.
  • It revitalizes herbal research and promotes the modernization and development of TCM.