Registration for exponential family functional data
Related Experiment Video
Updated: Feb 6, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Julia Wrobel1, Vadim Zipunnikov2, Jennifer Schrack3,4
1Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, U.S.A.
Abstract:
We introduce a novel method for separating amplitude and phase variability in exponential family functional data. Our method alternates between two steps: the first uses generalized functional principal components analysis to calculate template functions, and the second estimates smooth warping functions that map observed curves to templates. Existing approaches to registration have primarily focused on continuous functional observations, and the few approaches for discrete functional data require a pre-smoothing step; these methods are frequently computationally intensive. In contrast, we focus on the likelihood of the observed data and avoid the need for preprocessing, and we implement both steps of our algorithm in a computationally efficient way. Our motivation comes from the Baltimore Longitudinal Study on Aging, in which accelerometer data provides valuable insights into the timing of sedentary behavior. We analyze binary functional data with observations each minute over 24 hours for 592 participants, where values represent activity and inactivity. Diurnal patterns of activity are obscured due to misalignment in the original data but are clear after curves are aligned. Simulations designed to mimic the application indicate that the proposed methods outperform competing approaches in terms of estimation accuracy and computational efficiency. Code for our method and simulations is publicly available.
Related Concept Videos
Exponential Functions with Base e
Introduction to Exponential Functions
Protein Families
Protein Families
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Gene Families

