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Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
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Circulating Biomarkers for Tumor Angiogenesis: Where Are We?
Virginia Di Paolo1, Marta Colletti1, Valentina Ferruzzi1
1Department of Hematology/Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio, 4-00165 Rome, Italy.
Current Medicinal Chemistry
|August 22, 2018
Summary
New circulating biomarkers for angiogenesis are emerging, offering non-invasive ways to predict patient response to anti-angiogenic therapies and resistance. These markers could guide treatment strategies and improve patient outcomes.
Area of Science:
- Oncology
- Vascular Biology
- Biomarker Discovery
Background:
- Anti-angiogenic drugs offer clinical benefits but show variable patient responses.
- Dynamic, non-invasive biomarkers are needed to understand resistance and optimize treatment.
Purpose of the Study:
- To review current reports on circulating diagnostic and prognostic biomarkers for angiogenesis.
- To discuss the potential of non-invasive biomarkers in monitoring tumor treatment and guiding clinical strategy.
Main Methods:
- Literature review of recent evidence on circulating anti-angiogenic markers.
- Analysis of growth factor proteins, circulating microRNAs (miRNAs), and tumor-derived exosomes.
Main Results:
- Circulating biomarkers, including growth factors and miRNAs, show potential for non-invasive angiogenesis assessment.
- Tumor-derived exosomes are implicated in vascular remodeling and represent promising biomarkers.
Conclusions:
- Numerous circulating angiogenesis biomarkers have been identified.
- These biomarkers may help identify patients benefiting from anti-angiogenic treatment and predict resistance or adverse effects.
- Further research is needed to establish their clinical utility.
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