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Related Experiment Videos

Theophylline-induced hypercalcemia.

M L McPherson, S R Prince, E R Atamer

    Annals of Internal Medicine
    |July 1, 1986
    PubMed
    Summary
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    Theophylline toxicity can cause high calcium levels (hypercalcemia) by affecting beta-adrenergic pathways. These elevated calcium levels normalize as theophylline levels decrease.

    Area of Science:

    • Clinical Medicine
    • Pharmacology
    • Endocrinology

    Background:

    • Theophylline is a common medication with a narrow therapeutic index.
    • Theophylline toxicity can lead to various adverse effects.
    • The relationship between theophylline and serum calcium levels is not fully understood.

    Purpose of the Study:

    • To investigate the association between theophylline toxicity and hypercalcemia.
    • To explore the mechanism by which theophylline affects serum calcium.
    • To determine the role of beta-adrenergic regulation in theophylline-induced hypercalcemia.

    Main Methods:

    • Retrospective analysis of 60 patients hospitalized for theophylline toxicity over 2 years.
    • Monitoring of serum calcium and theophylline levels.

    Related Experiment Videos

  • Administration of propranolol to normal volunteers receiving theophylline to assess beta-adrenergic blockade.

    • Main Results:

    • Eleven of 60 patients with theophylline toxicity presented with hypercalcemia.
    • Serum calcium normalized in these patients as theophylline levels decreased.
    • A significant increase in serum calcium in normal volunteers on theophylline was reversed by propranolol, suggesting beta-adrenergic involvement.

    Conclusions:

    • Theophylline toxicity is associated with elevated serum calcium levels.
    • Theophylline appears to increase serum calcium through a mechanism involving beta-adrenergic regulation.
    • Further research is warranted to elucidate the precise molecular pathways involved.