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Progression of Gastric Acid Production in Preterm Neonates: Utilization of In-vitro Method

Murali R Palla1, Shashidhar Harohalli2, Tim N Crawford3

  • 1Pediatrics, University of Kentucky, Lexington, KY, United States.

Frontiers in Pediatrics
|August 23, 2018
PubMed

Insights

An in vitro method for measuring gastric pH in preterm infants is feasible and non-invasive. This technique allows for frequent testing and is useful for studying gastric acid production in premature babies.

Area of Science:

  • Neonatal Physiology
  • Gastroenterology
  • Pediatric Research

Background:

  • Limited research exists on gastric acid production in preterm infants.
  • Previous studies predominantly utilized invasive in vivo methods for gastric pH assessment.
  • Understanding gastric pH is crucial for managing feeding and potential complications in premature neonates.

Purpose of the Study:

  • To evaluate the feasibility of an in vitro method for gastric pH measurement in infants.
  • To assess gastric pH in preterm infants ≤ 28 weeks gestational age (GA).
  • To determine if gastric pH varies with GA, delivery mode, or antenatal steroid use.

Main Methods:

  • Prospective study involving extremely low birth weight (ELBW) infants.
  • Gastric aspirates collected pre-feeding on days 1, 3, 5, 7, 14, and 28 of life.
  • In vitro pH measurement using a pH electrode, with triplicate readings and mean calculation.

Main Results:

  • 29 infants ≤ 28 weeks GA or birth weight ≤ 1,000 g were enrolled.
  • No significant changes in gastric pH were observed over the 28-day study period.
  • Neither antenatal steroid administration nor mode of delivery impacted gastric acid pH.

Conclusions:

  • The in vitro method for gastric pH assessment is a viable, non-invasive alternative.
  • This technique enables more frequent and consistent gastric pH monitoring.
  • The method is suitable for investigating factors influencing gastric pH in neonates.

Keywords:
Invitro methodgastric pHpreterm infantsprogression of acidityreflux

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