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Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events
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Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling Events

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Random walker models for durotaxis.

Charles R Doering1,2,3, Xiaoming Mao3, Leonard M Sander1,2

  • 1Center for the Study of Complex Systems, University of Michigan, Ann Arbor, MI 48109-1107, United States of America.

Physical Biology
|August 23, 2018
PubMed
Summary
This summary is machine-generated.

Cellular durotaxis, movement towards stiffer tissue, requires sensing stiffness gradients. Simple models show that sensing stiffness values alone leads to inefficient cell migration, highlighting gradient sensing as the likely mechanism.

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Area of Science:

  • Cellular biology
  • Biophysics
  • Mechanobiology

Background:

  • Motile biological cells exhibit durotaxis, migrating towards stiffer substrate regions.
  • The precise mechanism driving durotaxis remains incompletely understood.
  • Existing models often simplify cell behavior to understand complex phenomena.

Purpose of the Study:

  • To investigate the mechanism of durotaxis using simplified persistent random walker models.
  • To determine if sensing stiffness gradients or stiffness values is essential for durotaxis.
  • To contrast model predictions with recent experimental claims.

Main Methods:

  • Development of a one-dimensional persistent random walker model.
  • Simulation of cell migration on substrates with varying stiffness.
  • Analysis of cell movement patterns based on stiffness sensing mechanisms.

Main Results:

  • Model results indicate that cells must sense the stiffness gradient to exhibit observed durotaxis.
  • Sensing only the local stiffness value results in significantly inefficient directed movement.
  • The persistent random walker model provides insights into different classes of cellular behavior.

Conclusions:

  • Gradient sensing is crucial for efficient durotaxis.
  • Sensing stiffness values alone is insufficient to explain experimental observations of durotaxis.
  • Gradient sensing is likely the evolutionarily selected mechanism for cell migration in tissues.