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MMP-9 gene rs3918242 polymorphism increases risk of stroke: A meta-analysis

Baohua Wang1, Yinhua Wang1, Lei Zhao1

  • 1Department of Critical Care Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, China.

Journal of Cellular Biochemistry
|August 23, 2018
PubMed

Insights

The matrix metalloproteinase-9 (MMP-9) rs3918242 gene variant is linked to a higher stroke risk, particularly in Asians and for ischemic stroke. This meta-analysis confirms the association, offering clarity on conflicting previous findings.

Area of Science:

  • Genetics and Genomics
  • Neurology
  • Cardiovascular Disease

Background:

  • The role of matrix metalloproteinase-9 (MMP-9) gene polymorphisms in stroke risk is debated.
  • Conflicting results exist regarding the association between MMP-9 rs3918242 polymorphism and stroke.
  • A comprehensive assessment is needed to clarify this relationship.

Purpose of the Study:

  • To evaluate the association between MMP-9 gene rs3918242 polymorphism and stroke risk using meta-analysis.
  • To investigate ethnic and stroke type specific risks associated with this polymorphism.

Main Methods:

  • A systematic literature search was conducted across PubMed, Embase, and CNKI.
  • Pooled odds ratios and 95% confidence intervals were calculated from 16 eligible studies.
  • Involved 3647 stroke patients and 3685 controls.

Main Results:

  • The MMP-9 rs3918242 polymorphism was significantly associated with an increased risk of stroke.
  • Stratification revealed a higher risk among Asian populations, but not Caucasians.
  • Subgroup analysis indicated an increased risk specifically for ischemic stroke.

Conclusions:

  • MMP-9 gene rs3918242 polymorphism is a risk factor for stroke.
  • The risk is more pronounced in Asian ethnicities and for ischemic stroke subtypes.
  • This meta-analysis provides robust evidence for the association.
Keywords:
matrix metalloproteinase-9 (MMP-9)meta-analysissingle-nucleotide polymorphism (SNP)stroke

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