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Updated: Feb 6, 2026
14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
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Immunological memory cells
Weronika Ratajczak1, Paulina Niedźwiedzka-Rystwej2, Beata Tokarz-Deptuła2
1Scientific Circle of Microbiologists, Faculty of Biology, University of Szczecin, Szczecin, Poland.
Central-European Journal of Immunology
|August 24, 2018
Summary
Immunological memory involves T, B, and natural killer (NK) cells for rapid antigen response. These cells are crucial for fighting pathogens, managing autoimmune diseases, and enabling vaccine therapy.
Area of Science:
- Immunology
- Cellular Biology
- Vaccinology
Background:
- Immunological memory is mediated by specialized lymphocytes and natural killer (NK) cells.
- These cells ensure a swift and potent response upon re-exposure to a specific antigen.
Purpose of the Study:
- To review the characteristics and roles of immunological memory cells.
- To highlight the involvement of T, B, and NK cells in immunity, autoimmunity, and tolerance.
Main Methods:
- Phenotypic and functional characterization of memory T, B, and NK cells.
- Review of existing literature on immunological memory mechanisms.
Main Results:
- Memory is established by distinct subsets of T lymphocytes, including central, effector, and tissue-resident memory cells.
- Evidence confirms immunological memory in NK cells, responding to haptens and viruses.
- Memory T, B, and NK cells play roles in pathogen defense, autoimmune conditions, and maternal-fetal tolerance.
Conclusions:
- Immunological memory cells are vital for adaptive immunity and vaccine efficacy.
- These cells are implicated in both protective immunity and the pathogenesis of autoimmune diseases.
- Understanding memory cell function is key for developing advanced immunotherapies and vaccines.
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