Related Experiment Video
Updated: Feb 6, 2026
12:45
Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat
Published on: July 19, 2012
36.6K
BMP7 expression in the adult rat brain.
Yuya Kusakawa1,2, Sumiko Mikawa1, Kohji Sato1
1Department of Tissue & Organ Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka 431-3192, Japan.
IBRO Reports
|August 24, 2018
Summary
Bone morphogenetic protein-7 (BMP7) is widely expressed in the adult rat central nervous system (CNS), particularly in astrocytes and neurons. This suggests BMP7 plays crucial roles in adult brain function.
Area of Science:
- Neuroscience
- Molecular Biology
- Developmental Biology
Background:
- Bone morphogenetic protein-7 (BMP7) is a member of the transforming growth factor-β (TGF-β) superfamily.
- BMP7 has diverse biological effects, but its expression in the adult central nervous system (CNS) is not well-characterized.
Purpose of the Study:
- To investigate the expression patterns of BMP7 in the adult rat CNS.
- To determine the cellular localization of BMP7 within the adult brain.
Main Methods:
- Immunohistochemistry was employed to detect BMP7 levels in adult rat brain tissue.
- Specific antibodies were used to visualize BMP7 protein distribution.
Main Results:
- Abundant BMP7 expression was observed in astrocytes throughout the CNS.
- Strong BMP7 signals were detected in neuropils of the gray matter.
- BMP7 expression was also found in specific neuronal populations, including oxytocin, dopaminergic, and noradrenergic neurons.
Conclusions:
- BMP7 is widely distributed in the adult mammalian CNS.
- These findings indicate that BMP7 likely plays significant roles in adult brain function, similar to its known roles in brain development.
Keywords:
AstrocyteBMP, bone morphogenetic proteinBMPR, bone morphogenetic protein receptorBSA, bovine serum albuminCNS, central nervous systemCSPGs, chondroitin sulfate proteoglycansGFAP, glial fibrillary acidic proteinIHC, immunohistochemistryIR, immunoreactivityImmunohistochemistryNeuronPB, phosphate bufferRT, room temperatureSVZ, subventricular zoneTGF-β, transforming growth factor βTTBS, Tris-buffered saline containing 0.05% Tween-20
Related Concept Videos
01:33Adult Stem Cells
33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
01:42What is Gene Expression?
196.9K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.9K
01:36What is Gene Expression?
11.5K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.5K
01:58Cell Specific Gene Expression
16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
02:48Expressing Solution Concentration
68.2K
A solute is a component of a solution that is typically present at a much lower concentration than the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.
68.2K
01:26Algebraic Expressions
362
Algebraic expressions are essential in mathematics. They represent relationships through variables, constants, and operations. These expressions help describe patterns and solve problems in various mathematical fields. Understanding their components, classifications, and operations allows for efficient simplification and manipulation.Each algebraic expression consists of individual parts, including numbers and symbols, that work together to form meaningful mathematical statements. The numerical...
362