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Updated: Feb 6, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Biomimetic Oxidative Coupling Cyclization Enabling Rapid Construction of Isochromanoindolenines
Jinxiang Ye1, Yuqi Lin1, Qing Liu1
1College of Chemistry , Fuzhou University , Fuzhou , Fujian 350116 , China.
Abstract:
Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to complex isochromanoindolenine scaffolds in moderate to excellent yields. The reaction proceeds smoothly and rapidly (complete within minutes) in an open flask. This operationally simple protocol is scalable and compatible with a wide range of functional groups. Late-stage functionalization of a pharmacologically relevant molecule is also demonstrated.
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