Related Experiment Video
Updated: Feb 6, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
NLRP3 inflammasome: A therapeutic option for kidney disease?
Neudo Buelvas-Jiménez1, Raibel J Suárez-Useche2, José R Vielma-Guevara3
1Lic. Biología. M.Sc. en Biología Celular. Laboratorio de Inmunobiología, Centro de Investigaciones Biomédicas (CIB), Instituto Venezolano de Investigaciones Científicas (IVIC), Hospital Universitario de Maracaibo. Maracaibo, Venezuela. buelvasneudo@gmail.com.
Objective:
To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.
Methods:
Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis, amyloidosis, Alzheimer's disease); the systematic review was made searching in the databases PubMed and SciELO for the following terms: "The NLRP3 inflammasome therapeutic for kidney disease", "NLRP3 nflammasome in kidney disease" in PubMed, and "Inflammasome" for Scielo.
Results:
146 documents were found, althoughonly 34 matched the working hypothesis concerning the NLRP3 inflammasome as a central component of various diseases in humans, with potential therapeutic use. The NLRP3 inflammasome is responsible for the maturation of inflammatory pro-interleukin IL-1 β and IL-18, which can be triggered by aggregated or crystalline materials (particles), and by various microorganisms and toxins derived from these; however, the way how activation mechanisms work is not completely clear.
Conclusions:
Research on new therapies that focus on removing or inhibiting inflammasome components, both individually and together, is proposed.
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