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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease IV: Nursing Management01:20

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Rheumatic Heart Disease III: Medical Management01:21

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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Attribution Theory00:56

Attribution Theory

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Behavior is a product of both the situation (e.g., cultural influences, social roles, and the presence of bystanders) and of the person (e.g., personality characteristics). Subfields of psychology tend to focus on one influence or behavior over others. Situationism is the view that our behavior and actions are determined by our immediate environment and surroundings. In contrast, dispositionism holds that our behavior is determined by internal factors (Heider, 1958).
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Related Experiment Video

Updated: Feb 6, 2026

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
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Challenging cases in rheumatic pregnancies.

Cuoghi Edens1,2, Bruna Costa Rodrigues3,4, Marcela Ignacchiti Lacerda3,4

  • 1Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children's Hospital.

Rheumatology (Oxford, England)
|August 24, 2018
PubMed
Summary
This summary is machine-generated.

Managing autoimmune diseases like SLE during pregnancy presents unique challenges. Careful multidisciplinary care and pre-conception counseling are crucial for optimizing maternal and fetal outcomes in complex rheumatologic cases.

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Area of Science:

  • Rheumatology
  • Obstetrics
  • Immunology

Background:

  • Pregnancy in women with autoimmune diseases, particularly Systemic Lupus Erythematosus (SLE), poses significant medical challenges.
  • Managing co-existing conditions like pulmonary arterial hypertension and thrombotic disorders complicates patient care.

Observation:

  • Three complex cases of SLE in pregnancy are presented.
  • Case 1: SLE with pulmonary arterial hypertension.
  • Case 2: SLE with portal hypertension secondary to portal vein thrombosis related to Antiphospholipid Syndrome (APS).
  • Case 3: SLE with atypical hemolytic uremic syndrome (aHUS)-induced thrombotic microangiopathy.

Findings:

  • Treatment of SLE and associated complications during pregnancy requires a multidisciplinary approach.
  • Adverse outcomes in complex rheumatologic pregnancies can be mitigated with careful medical management.
  • Even with intensive interventions like preterm delivery, some conditions like aHUS-induced thrombotic microangiopathy may not improve.

Implications:

  • Pre-conception counseling is vital for discussing disease management, medication, and the advisability of pregnancy.
  • Optimizing health outcomes for women with autoimmune diseases necessitates a proactive and integrated care strategy.
  • Further research into managing these rare and complex obstetric-rheumatologic scenarios is warranted.