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Small Heat Shock Protein16.3 of Mycobacterium tuberculosis: After Two Decades of Functional Characterization

Babban Jee1, Yogesh Singh2, Renu Yadav3

  • 1Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|August 24, 2018
PubMed

Insights

Small heat shock proteins (sHSPs) are vital for Mycobacterium tuberculosis survival and virulence. Targeting sHSP16.3 offers a promising strategy for developing new tuberculosis therapeutics and diagnostics.

Area of Science:

  • Molecular Biology
  • Immunology
  • Microbiology

Background:

  • Small heat shock proteins (sHSPs) are molecular chaperones with a conserved alpha-crystallin domain.
  • Mycobacterium tuberculosis (MTB), the cause of tuberculosis, possesses two sHSPs: sHSP16.3 and Acr2.
  • sHSP16.3 is critical for MTB survival during dormancy, growth, virulence, and cell wall thickening.

Purpose of the Study:

  • To comprehensively analyze the attributes of MTB's sHSP16.3.
  • To highlight research gaps for future therapeutic and diagnostic development.
  • To provide evidence for sHSP16.3 as a drug target.

Main Methods:

  • Literature review and analysis of existing data on sHSP16.3.
  • Examination of sHSP16.3's role in MTB physiology and host interaction.
  • Assessment of sHSP16.3's immunogenic properties and diagnostic potential.

Main Results:

  • sHSP16.3 plays a crucial role in MTB's survival, virulence, and dormancy.
  • The protein is immunogenic and consistently detected in patient sera.
  • sHSP16.3 presents a viable target for novel therapeutic interventions against TB.

Conclusions:

  • sHSP16.3 is a key factor in MTB pathogenesis and survival.
  • Its immunogenicity and essential role make it a promising candidate for TB vaccine development and diagnostics.
  • Further research into sHSP16.3 is warranted for novel anti-TB strategies.
Keywords:
DiagnosisDormancyDrug targetMycobacterium tuberculosisVaccinesHSP16.3

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