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Published on: December 11, 2017
Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass
Anton A Gryaznov1,2, Ayman Saeyeldin1, Mohamed Abdelbaky1
1Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
Insights
Aortic stenosis is a common heart valve disorder. This review examines the crucial role of anticoagulation in managing complications following aortic valve replacement surgery.
Area of Science:
- Cardiology
- Cardiac Surgery
- Pharmacology
Background:
- Valvular heart disease affects millions globally, with aortic stenosis being the most prevalent.
- Current guidelines guide treatment for aortic stenosis based on patient risk and symptom severity.
- Aortic valve replacement (AVR) using biological valves is increasingly common.
Purpose of the Study:
- To review the impact of anticoagulation strategies on patient outcomes after surgical AVR.
- To highlight the importance of appropriate anticoagulant selection post-AVR.
Main Methods:
- Literature review of studies on anticoagulation after AVR.
- Analysis of immediate and remote complications associated with different anticoagulation regimens.
Main Results:
- Anticoagulation plays a significant role in managing complications after AVR.
- The choice of anticoagulant impacts both short-term and long-term patient health.
Conclusions:
- Optimizing anticoagulation is essential for improving outcomes in patients undergoing AVR.
- Further research into anticoagulation protocols post-AVR is warranted.
Abstract:
Valvular heart disease is a common pathologic condition that affects 6 million people in the United States and more than 100 million worldwide. The most common valvular disorder is aortic stenosis. Current American and European guidelines recommend surgical management for symptomatic aortic stenosis with low risk of perioperative complications and endovascular intervention for high-risk patients with multiple comorbidities. Considering the increasing volume of aortic valve replacement (AVR) with biological valves, it is very important to select the appropriate anticoagulant after surgical AVR. In this article, we review the impact of anticoagulation on immediate and remote complications after AVR.
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