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Far infrared-emitting ceramics decrease Freund's adjuvant-induced inflammatory hyperalgesia in mice through cytokine
Ralph Fernando Rosas1, Aline Armiliato Emer1, Ana Paula Batisti1
1Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça 88137-272, Santa Catarina, Brazil; Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça 88137-272, Santa Catarina, Brazil.
Journal of Integrative Medicine
|August 25, 2018
Summary
Far infrared-emitting ceramics (cFIRs) effectively reduced pain and swelling in a mouse model of inflammation. These analgesic effects were mediated through adenosine and cannabinoid receptors, suggesting cFIRs as a potential treatment for inflammatory pain.
Area of Science:
- Biomedical Science
- Pain Research
- Inflammation Studies
Background:
- Persistent inflammatory hyperalgesia is a debilitating condition.
- Far infrared-emitting ceramics (cFIRs) are explored for therapeutic potential.
- Understanding the mechanisms of cFIRs' effects is crucial for clinical application.
Purpose of the Study:
- To evaluate the analgesic and anti-inflammatory effects of cFIRs.
- To investigate the underlying neurobiological mechanisms of cFIRs' therapeutic actions.
- To assess cFIRs' impact on inflammatory markers and pain pathways.
Main Methods:
- Mice received complete Freund's adjuvant (CFA) to induce inflammatory hyperalgesia.
- cFIRs were applied via a specialized pad for pain and edema assessment.
- Levels of TNF-α, IL-1β, and IL-10 were measured.
- Antagonists for adenosine (caffeine, DPCPX), cannabinoid (AM281, AM630), and opioid (naloxone) receptors were used to probe mechanisms.
Main Results:
- cFIRs significantly reduced mechanical hyperalgesia and edema in CFA-treated mice.
- cFIRs decreased pro-inflammatory cytokines TNF-α and IL-1β.
- cFIRs increased anti-inflammatory cytokine IL-10.
- Pretreatment with receptor antagonists blocked the analgesic effects of cFIRs.
Conclusions:
- cFIRs demonstrate significant analgesic and anti-inflammatory properties.
- The therapeutic effects of cFIRs are mediated via adenosine and cannabinoid receptor pathways.
- These findings support the use of cFIRs for managing painful inflammatory conditions.