Related Experiment Video
Updated: Feb 6, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Refractory Palmoplantar Pustular Psoriasis Treated With High-Dose Ustekinumab After Initial Failure
Michal Bohdanowicz1, Dusan Sajic2
11 Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Abstract:
Palmoplantar pustular psoriasis (PPPP) is a form of psoriasis that can be difficult to treat. We describe a case of PPPP in a patient who failed multiple therapies, including ustekinumab. The patient subsequently developed inflammatory bowel disease (IBD), and restarting ustekinumab, with inflammatory bowel disease loading doses and optimization, resulted in complete resolution of her PPPP. This success occurred after she developed tachyphylaxis against the usual dosing of ustekinumab, demonstrating a recapture of the treatment response.
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