Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transsphenoidal surgery for Cushing's disease.

R Fahlbusch, M Buchfelder, O A Müller

    Journal of the Royal Society of Medicine
    |May 1, 1986
    PubMed
    Summary

    Transsphenoidal surgery effectively treats Cushing's disease by removing pituitary microadenomas. This approach achieved a 77% remission rate, demonstrating its efficacy and safety for managing this complex endocrine disorder.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ENDOCRINE DISTURBANCES IN PARASELLAR MENINGIOMAS AND THE EFFECT OF TRANSSPHENOIDAL DECOMPRESSION OPERATIONS.

    Acta endocrinologica (Bucharest, Romania : 2005)·2026
    Same author

    Microsurgical treatment of cranial and spinal dural arteriovenous fistulas for acute occlusion: a single institution's experience.

    Neurological research·2022
    Same author

    Typing of inflammatory lesions of the pituitary.

    Pituitary·2021
    Same author

    ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy.

    European journal of endocrinology·2021
    Same author

    The optimal surgical techniques for pituitary tumors.

    Best practice & research. Clinical endocrinology & metabolism·2019
    Same author

    SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.

    Endocrine-related cancer·2019

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Oncology

    Background:

    • Cushing's disease is a serious endocrine disorder caused by excess cortisol.
    • Diagnosis relies on dynamic testing, particularly dexamethasone suppression tests.
    • Transsphenoidal surgery is a primary treatment modality.

    Purpose of the Study:

    • To evaluate the efficacy and outcomes of transsphenoidal surgery for Cushing's disease.
    • To assess remission rates and complications associated with the surgical procedure.
    • To analyze the impact of surgery on pituitary function.

    Main Methods:

    • Retrospective analysis of 101 patients with Cushing's disease undergoing transsphenoidal surgery.
    • Diagnosis confirmed by dynamic endocrine testing (dexamethasone suppression).
    • Intraoperative ACTH measurements used to monitor surgical success.

    Main Results:

    • Selective removal of pituitary microadenomas in 96% of patients.
    • Achieved a 74% initial remission rate, with an overall 77% remission after secondary procedures.
    • Low surgical complication rate despite significant patient morbidity; 2 postoperative deaths.
    • Improvement in pituitary function observed post-surgery.

    Conclusions:

    • Transsphenoidal surgery is a highly effective treatment for Cushing's disease, yielding high remission rates.
    • The procedure is associated with low morbidity and mortality when performed by experienced surgeons.
    • Selective adenomectomy offers a favorable outcome, with secondary interventions improving overall success.

    Related Experiment Videos