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ENDOCRINE DISTURBANCES IN PARASELLAR MENINGIOMAS AND THE EFFECT OF TRANSSPHENOIDAL DECOMPRESSION OPERATIONS
M Repschlaeger1, V Binder1, Y Zhao1
1Erlangen University Hospital - Department of Neurosurgery, Erlangen, Germany.
Acta Endocrinologica (Bucharest, Romania : 2005)
|March 9, 2026
Summary
Transsphenoidal decompression effectively manages parasellar meningiomas, improving clinical symptoms like diplopia and resolving endocrinological dysfunctions such as hyperprolactinemia. This procedure offers a low complication rate for initial treatment.
Area of Science:
- Neurosurgery
- Endocrinology
- Oncology
Background:
- Parasellar meningiomas can cause significant clinical and endocrinological dysfunctions.
- Transsphenoidal decompression is a surgical approach to address these tumors.
Purpose of the Study:
- To evaluate the clinical and endocrinological outcomes following transsphenoidal decompression for parasellar meningioma.
Main Methods:
- Retrospective analysis of 40 patients (30 women, 10 men; mean age 55.9) undergoing decompressive transsphenoidal microsurgery.
- Preoperative and postoperative assessments at one week and three months.
Main Results:
- Diplopia, the most common symptom (47.5%), improved in 21.1% of patients.
- Hyperprolactinemia (52.5% preoperative) reduced to 20% at first follow-up.
- Other endocrine axes showed significant improvement, with no negative impact on somatotropic and thyrotropic axes.
Conclusions:
- Transsphenoidal decompression is a beneficial and low-complication initial management strategy for cavernous sinus meningiomas.
- The procedure demonstrates efficacy in resolving hormonal imbalances and improving neurological symptoms.
