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Updated: Feb 6, 2026

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

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Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing

Michelle L Kimberland1, Wangfang Hou1, Adolfo Alfonso-Pecchio1

  • 1Target Sciences, GlaxoSmithKline R&D, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

Journal of Biotechnology
|August 25, 2018
PubMed

Keywords:
Cell engineeringClonal variationsGene targetingGenetic modificationsIndelsTarget specificity

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