Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study.

Area of Science:

• Genetics
• Cardiology
• Population Health

Background:

• Coronary artery disease (CAD) is a significant health concern.
• Understanding genetic factors in CAD is crucial for prevention and treatment.
• Genetic homozygosity and morphogenetic variability may play a role in CAD susceptibility.

Purpose of the Study:

• To evaluate genetic homozygosity and morphogenetic variability in CAD patients compared to a control group.
• To assess the relationship between risk factors and genetic variability in CAD.
• To analyze ABO blood type distribution in CAD patients and controls.

Main Methods:

• Analyzed 17 homozygously-recessive characteristics (HRC) in 148 CAD patients and 156 controls.
• Utilized HRC testing to assess individual phenotype and morphogenetic variability.
• Investigated risk factors including hypertension, diabetes mellitus, hyperlipidemia, and smoking.

Main Results:

• CAD patients showed significantly higher mean HRC values (4.24 ± 1.59) and lower variability (37.50%) than controls (3.75 ± 1.69; 45.07%).
• Significant differences in HRC variations were observed between CAD patients and controls (χ² = 169.144; p < 0.01).
• Blood type A was a significant predictor for CAD (OR = 1.75), while blood type O was associated with controls (OR = 0.43).

Conclusions:

• CAD patients demonstrate a higher degree of recessive homozygosity compared to controls.
• Increasing numbers of risk factors are associated with significant variations in recessive homozygosity.
• Genetic factors, including blood type, may influence CAD development.