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Sodium glucose cotransporter 2 inhibition and renal ischemia: implications for future clinical trials

Daniël H van Raalte1, David Z I Cherney2

  • 1Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.

Kidney International
|August 26, 2018
PubMed

Insights

Sodium glucose cotransporter 2 inhibitors show kidney protection beyond blood sugar control. Lusogliflozin demonstrated renoprotective effects in a nondiabetic model, suggesting benefits for chronic kidney disease.

Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Sodium glucose cotransporter 2 (SGC2) inhibitors offer renal protection independent of glycemic control.
  • Interest is growing in SGC2 inhibitors for nondiabetic kidney disease due to natriuresis-mediated effects.
  • These effects include improvements in blood pressure, proteinuria, and renal function.

Purpose of the Study:

  • To investigate the renoprotective effects of SGC2 inhibitors in nondiabetic conditions.
  • To explore the mechanistic insights of lusogliflozin in a kidney injury model.

Main Methods:

  • Utilized an ischemia-reperfusion injury model in nondiabetic subjects.
  • Administered the SGC2 inhibitor lusogliflozin.

Main Results:

  • Lusogliflozin exhibited significant renoprotective effects.
  • These effects were observed under nondiabetic conditions, independent of glucose-lowering.

Conclusions:

  • SGC2 inhibitors, like lusogliflozin, possess intrinsic renal protective properties.
  • These findings support the potential utility of SGC2 inhibitors in managing chronic kidney disease, even in nondiabetic patients.

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