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CYP3A4*1B Polymorphism and Cancer Risk: A Meta-Analysis Based on 55 Case-control Studies
Yuan Zheng1, Yi Xu2, Bu-Yu Zhou3
1Shaanxi Provincial Centre for Disease Control and Prevention, Xi'an, China 860107810@qq.com.
Annals of Clinical and Laboratory Science
|August 26, 2018
Summary
The CYP3A4*1B polymorphism may slightly increase cancer risk, particularly leukemia. This meta-analysis of 55 studies found a significant association in the dominant genetic model.
Area of Science:
- Genetics
- Cancer Epidemiology
- Pharmacogenomics
Background:
- The CYP3A4*1B polymorphism's link to cancer risk is debated.
- Previous studies show conflicting results, necessitating a comprehensive analysis.
Purpose of the Study:
- To clarify the association between CYP3A4*1B polymorphism and overall cancer risk.
- To investigate potential influences of ethnicity and cancer type on this association.
Main Methods:
- A systematic literature search was conducted on PubMed.
- A meta-analysis of 55 studies, encompassing 22,072 cancer cases and 25,433 controls, was performed.
- Subgroup analyses were conducted based on ethnicity and cancer type.
Main Results:
- A significant association between CYP3A4*1B and cancer risk was observed in the overall population under the dominant genetic model (OR=1.142, 95% CI=1.006-1.295).
- Subgroup analysis by cancer type indicated an increased risk for leukemia in dominant and heterozygous models.
- Excluding studies with controls not in Hardy-Weinberg Equilibrium (HWE) strengthened the association in dominant and heterozygous models.
Conclusions:
- The CYP3A4*1B polymorphism may contribute modestly to cancer susceptibility.
- Leukemia appears to be a specific cancer type where this polymorphism shows a more pronounced association.
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