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Synthesis of (±)-Merrilactone A by a Desymmetrization Strategy
Wentan Liu1,2, Bo Wang1,3
1Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 26, 2018
Abstract:
A concise synthesis of (±)-merrilactone A has been accomplished featuring desymmetrization of a Cs -symmetric dilactone, RhI -catalyzed intramolecular hydroacylation of a 4-alkynal, and TiIII -mediated reductive radical cyclization of epoxy-allene.
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