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Updated: Feb 6, 2026
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
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Long non-coding RNA CASC2 in solid tumors: A meta-analysis
Chaojie Liang1, Jinghong Zhang1, Hua Ge1
1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Summary
This meta-analysis found that low expression of cancer susceptibility 2 (CASC2) is linked to advanced cancer characteristics. Higher CASC2 levels correlate with better patient survival, suggesting CASC2 as a potential cancer biomarker.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA cancer susceptibility 2 (CASC2) is frequently downregulated in human solid tumors.
- Previous studies had limited sample sizes, leaving the role of CASC2 in cancer unclear.
Purpose of the Study:
- To conduct a meta-analysis to explore the role of CASC2 in solid tumors.
- To investigate the association between CASC2 expression and clinicopathological characteristics and prognosis of cancer patients.
Main Methods:
- Systematic literature search across multiple databases (PubMed, Medline, Web of Science, EMBASE, etc.).
- Meta-analysis of 15 studies involving 1158 patients.
- Analysis of The Cancer Genome Atlas (TCGA) dataset for CASC2 expression.
Main Results:
- Low CASC2 expression correlated with larger tumor size, lower differentiation, and advanced TNM stage.
- High CASC2 expression was associated with improved overall survival (OS) and disease-free survival (DFS).
- CASC2 was identified as an independent predictive factor for OS.
Conclusions:
- Reduced CASC2 expression is linked to unfavorable clinicopathological features in human cancers.
- CASC2 shows potential as a prognostic biomarker for cancer.
- Further research is recommended to validate these findings.
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