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Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius
Hoai Thi Nguyen1, Linh Thuy Thi Tran2, Duc Viet Ho1
1Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Viet Nam.
Abstract:
Pogostemins A-C (1-3), three new meroterpenoids with pyrone-sesquiterpenoid hybrid skeletons, were isolated from the aerial parts of Pogostemon auricularius. Their chemical structures were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 1 showed significant cytotoxicities against the human colon adenocarcinoma SW-480, epidermoid carcinoma KB, gastric cancer AGS, hepatoma cancer Hep-G2, and lung cancer LU-1 cell lines with IC50 values of 7.21, 8.49, 9.44, 11.75, and 12.76 μg/mL, respectively.
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