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Delayed hyperthermia from chlorfenapyr overdose
James Chomin1, William Heuser2, Joshua Nogar1
1Department of Clinical Toxicology, Long Island Jewish Medical Center, Northwell Health, United States of America; Department of Emergency Medicine, Long Island Jewish Medical Center, Northwell Health, United States of America.
The American Journal of Emergency Medicine
|August 28, 2018
Summary
Chlorfenapyr pesticide poisoning is highly lethal in humans, with a 100% mortality rate reported. Early decontamination is crucial, as late-stage treatment, including hemodialysis, proved ineffective in a fatal case.
Area of Science:
- Toxicology
- Environmental Health
- Emergency Medicine
Background:
- Chlorfenapyr is an organochlorine pesticide acting as a mitochondrial uncoupler.
- Limited human data exists for chlorfenapyr toxicity, with previous reports suggesting a high mortality rate.
- A 7-10 day quiescent period precedes severe toxicity in reported cases.

