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Updated: Feb 6, 2026
10:22
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
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[INVESTIGATION OF TREATMENT GOAL IN ALLERGEN IMMUNOTHERAPY FOR JAPANESE CEDAR POLLINOSIS]
Minoru Gotoh1, Kimihiro Okubo2, Yoshitaka Okamoto3
1Department of Otorhinolaryngology, Nippon Medical School Tama Nagayama Hospital.
Arerugi = [Allergy]
|August 28, 2018
Summary
Establishing treatment goals for Japanese cedar pollinosis (allergic rhinitis) using allergen immunotherapy is crucial. A total nasal symptom medication score (TNSMS) below 3 indicates mild symptoms, suggesting successful therapeutic effects.
Area of Science:
- Allergy and Immunology
- Clinical Pharmacology
- Otorhinolaryngology
Background:
- Limited data exists on treatment goals for Japanese cedar pollinosis managed with allergen immunotherapy.
- Therapeutic effects are often assessed via subjective symptoms in clinical practice.
Purpose of the Study:
- To investigate informative treatment goals for Japanese cedar pollinosis in clinical practice.
- Utilize results from the TO-194SL phase III clinical trial to establish these goals.
Main Methods:
- Correlate the total nasal symptom medication score (TNSMS) with secondary endpoints: severe symptom days, quality of life (QOL) scores, and overall subject evaluation.
- Perform stratified analyses of secondary endpoints against TNSMS and the cedar pollen season.
Main Results:
- A significant correlation was observed between TNSMS and the evaluated secondary endpoints.
- TNSMS generally remained below 3 (mild) throughout the pollen season when secondary endpoints met their thresholds.
Conclusions:
- Specific evaluation items can help patients recognize the therapeutic effects of allergen immunotherapy.
- These selected items can serve as effective treatment goals in clinical practice for Japanese cedar pollinosis.
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