Related Experiment Video

Updated: Feb 6, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

The viral approach to breast cancer immunotherapy

Atefeh Arab1, Nima Behravan2, Atefeh Razazn1

  • 1Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of Cellular Physiology
|August 28, 2018
PubMed

Insights

Oncolytic virus (OV) therapy and phage display systems show promise for cancer treatment. These advanced methods can initiate antitumor immune responses and serve as novel cancer vaccines, offering new therapeutic strategies.

Area of Science:

  • Oncology
  • Immunotherapy
  • Virology

Background:

  • Breast cancer remains a leading global health concern, necessitating innovative treatment strategies.
  • Oncolytic viruses (OVs) and phage display systems are emerging as powerful therapeutic modalities.
  • These technologies have the potential to induce systemic antitumor immune responses and act as cancer vaccines.

Purpose of the Study:

  • To review advancements in oncolytic virus (OV) therapies and bacterial virus display systems for cancer immunotherapy.
  • To highlight the potential of these novel approaches in cancer prevention and treatment.
  • To discuss the combination of OV therapy with other immunotherapies like checkpoint inhibitors and cancer vaccines.

Main Methods:

  • Investigating oncolytic viruses (OVs) from various families for therapeutic potential.
  • Utilizing phage display to present immunologic peptides (e.g., E75, AE37, GP2) derived from HER2/neu.
  • Testing peptide-based vaccines derived from HER2/neu for the treatment of breast cancer xenografts in mice.

Main Results:

  • Oncolytic viruses (OVs) demonstrate the ability to induce systemic antitumor immune responses.
  • Phage display systems offer a novel strategy for cancer vaccine delivery by presenting antigens.
  • Experimental vaccines derived from HER2/neu peptides showed potential in preclinical breast cancer models.

Conclusions:

  • Oncolytic virus (OV) therapy and phage display represent promising advancements in cancer immunotherapy.
  • Multimodal therapies combining OV therapy with immune checkpoint inhibitors and cancer vaccines hold significant future potential.
  • Bacterial virus display systems provide a strong platform for developing new cancer vaccines and therapeutics.
Keywords:
bacteriophagebreast canceroncolytic virusphage displayvaccine

More Related Videos

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K
Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.8K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.6K
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.9K
Frustration and Conflict: Approach-Approach, Approach-Avoidance01:20

Frustration and Conflict: Approach-Approach, Approach-Avoidance

Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
539
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
799