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Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Targeting Breast Cancer Stem Cells: A Methodological Perspective.

Marco A Velasco-Velázquez1,2, Inés Velázquez-Quesada1,3, Luz X Vásquez-Bochm1,4

  • 1Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad de Mexico, Mexico.

Current Stem Cell Research & Therapy
|August 28, 2018
PubMed
Summary

Cancer Stem Cells (CSCs) drive breast cancer growth and heterogeneity. This review covers methods to study CSCs and evaluate drugs targeting them for new cancer therapies.

Keywords:
CSC differentiationCSC selective toxicityCancer stem cellsanticancer drugsbreast tumorsself-renewal.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Cancer Stem Cells (CSCs) are a critical subpopulation driving tumor heterogeneity and growth.
  • CSCs are recognized as key therapeutic targets for novel breast cancer treatments.
  • Understanding CSC biology is essential for developing effective anti-cancer drugs.

Purpose of the Study:

  • To review experimental methods for studying breast CSC properties.
  • To discuss the preclinical evaluation of CSC-targeting drugs.
  • To highlight the importance of CSCs in breast cancer therapy development.

Main Methods:

  • Literature review of established and emerging techniques for CSC identification and characterization.
  • Analysis of functional assays to assess CSC properties like self-renewal and differentiation.
  • Evaluation of preclinical models for testing drug efficacy against CSCs.

Main Results:

  • Various methods exist to study CSCs, including in vitro and in vivo models.
  • Assays assessing stemness properties are crucial for drug screening.
  • Preclinical evaluation of CSC-targeting drugs relies on understanding these properties.

Conclusions:

  • Comprehensive study of CSC properties is vital for therapeutic advancements.
  • Effective preclinical evaluation of breast CSC-targeting drugs requires robust methodologies.
  • Targeting CSCs holds significant promise for improving breast cancer treatment outcomes.