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Takayasu's disease effects on the kidneys: current perspectives
Gioacchino Li Cavoli1, Giuseppe Mulè2, Mario Giuseppe Vallone3
1Nephrology, Dialysis and Renal Transplant Department, Civico and Di Cristina Hospital, Palermo, Italy, gioacchinolicavoli@libero.it.
International Journal of Nephrology and Renovascular Disease
|August 28, 2018
Summary
Takayasu arteritis, a chronic vasculitis, frequently causes kidney problems like renovascular hypertension. Assessing disease activity and identifying optimal treatments for renal involvement remain challenging.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Takayasu arteritis (TA) is a chronic vasculitis of unknown cause.
- Renal complications, particularly renovascular hypertension, are common in TA.
- Assessing TA activity is difficult due to potential progression from inflammation to fixed injury.
Purpose of the Study:
- To review current understanding of renal involvement in Takayasu arteritis.
- To highlight challenges in diagnosing and managing TA-related kidney disease.
- To discuss therapeutic perspectives for renal manifestations of TA.
Main Methods:
- Literature review of studies on Takayasu arteritis and renal disease.
- Analysis of clinical presentations and diagnostic challenges.
- Synthesis of current treatment strategies and future directions.
Main Results:
- Renovascular hypertension is the primary renal issue in TA.
- Active vascular inflammation can be present without overt clinical signs of active disease.
- Optimal therapeutic options for TA's renal manifestations are not yet established.
Conclusions:
- Renal involvement is a significant concern in Takayasu arteritis.
- Accurate assessment of TA activity is crucial for timely intervention.
- Further research is needed to define best practices for managing TA-related renal disease.