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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Related Experiment Video

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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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NOTCH and Graft-Versus-Host Disease.

Mauro Di Ianni1,2, Beatrice Del Papa3, Stefano Baldoni4

  • 1Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy.

Frontiers in Immunology
|August 28, 2018
PubMed
Summary

The NOTCH pathway regulates T cells, which are key in graft-versus-host disease (GvHD) after stem cell transplants. Targeting NOTCH signaling offers a potential new therapy for acute GvHD.

Keywords:
HSCTNOTCHgraft-versus-host diseasegraft-versus-leukemiatolerance

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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
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Area of Science:

  • Immunology
  • Cell Signaling
  • Hematology

Background:

  • Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies.
  • T cells are critical mediators in the development of graft-versus-host disease (GvHD).

Purpose of the Study:

  • To review the role of NOTCH signaling in acute GvHD.
  • To explore NOTCH signaling as a potential therapeutic target for GvHD.

Main Methods:

  • Literature review of studies on NOTCH signaling and T cell function.
  • Analysis of the involvement of NOTCH pathway in GvHD pathogenesis.

Main Results:

  • NOTCH signaling is identified as a novel regulator of acute GvHD.
  • The NOTCH pathway influences T cell differentiation and function relevant to GvHD.

Conclusions:

  • NOTCH signaling plays a significant role in the development of acute GvHD.
  • Targeting the NOTCH pathway presents a promising therapeutic strategy for managing GvHD.