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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

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Site-specific delivery of polymeric encapsulated microorganisms: a patent evaluation of US20170165201A1

Inderbir Singh1, Pradeep Kumar2, Viness Pillay2

  • 1a Department of Pharmaceutics, Chitkara College of Pharmacy , Chitkara University , Patiala , India.

Expert Opinion on Therapeutic Patents
|August 28, 2018
PubMed
Abstract

Insights

This study developed a novel microencapsulation method for Bacillus coagulans using mucoadhesive and pH-responsive polymers. This technology enhances probiotic delivery and survival in the gastrointestinal tract.

Area of Science:

  • Biotechnology
  • Materials Science
  • Microbiology

Background:

  • Probiotics are live microorganisms with therapeutic benefits, but their survival is limited by the gastrointestinal environment.
  • Microencapsulation protects probiotics, and mucoadhesive/pH-responsive polymers can enhance targeted delivery and retention.
  • Layer-by-layer assembly offers a promising strategy for advanced probiotic formulations.

Purpose of the Study:

  • To develop and evaluate a novel microencapsulation system for Bacillus coagulans using layer-by-layer assembly.
  • To utilize mucoadhesive polymers (chitosan, alginate) and pH-responsive polymers (Eudragit EPO, Eudragit L100) for enhanced probiotic delivery.
  • To assess the stability, mucoadhesion, and pH-responsive release of the encapsulated probiotics.

Main Methods:

  • Layer-by-layer assembly of chitosan, alginate, Eudragit EPO, and Eudragit L100 to encapsulate Bacillus coagulans.
  • Evaluation of layer stability, mucoadhesion properties, and protection against biological insults.
  • Assessment of pH-responsive layer removal and in vitro performance using a 3D intestinal tissue model.

Main Results:

  • Successful encapsulation of Bacillus coagulans using a layer-by-layer approach.
  • Demonstrated mucoadhesive properties and enhanced protection of probiotics.
  • Confirmed pH-responsive release of probiotics, indicating site-specific delivery potential.
  • Positive in vitro results in a 3D intestinal model suggest improved bacterial delivery.

Conclusions:

  • The developed layer-by-layer microencapsulation system effectively protects Bacillus coagulans and offers mucoadhesive and pH-responsive release properties.
  • This technology shows potential for improved oral probiotic delivery and therapeutic applications.
  • Further in vivo studies are recommended to confirm clinical applicability.
Keywords:
Probioticslayer-by-layermicrorganismsmucoadhesive polymerpH responsive polymer

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