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Updated: Feb 6, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
High-Yielding Synthesis of Chiral Donor-Acceptor Catenanes
Mehrafarin Eilbigi Dehkordi1, Vijay Luxami1, G Dan Pantoş1
1Department of Chemistry , University of Bath , Calverton Down , Bath BA27AY , U.K.
Abstract:
We report the synthesis of [2]catenanes (Hopf links) in water utilizing disulfides and aromatic donor-acceptor interactions. The electron-rich dialkoxynaphthalene (DN) building blocks interact with electron-deficient naphthalenediimide (NDI) moieties connected by a polyamine chain. We study the effect of the polyamine linkers on the behavior of the library. The polyamine's length and the number of nitrogen atoms in the chain affect the library distribution, leading in some cases to the assembly of catenanes in up to 93% yield.
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