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Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
Published on: November 3, 2014
Crotalus durissus sp. rattlesnake venom induces toxic injury in mouse sperm
Fábio Henrique Fernandes1, Eduardo Bustos-Obregon2, Rosemary Matias3
1São Paulo State University - UNESP, Medical School, Department of Pathology, Rubião Junior, 18618-000, Botucatu, São Paulo, Brazil.
Abstract:
Accidents involving snakebites constitute a serious public health problem in many regions around the world. However, there are no study about a possible action of snake venom on the reproductive system. Herein we show that Crotalus durissus sp. (Linnaeus) rattlesnake venom (25 μg/kg of body weight) affected chromatin condensation, and increased the number of sperm with abnormal morphology and the sperm count. In conclusion, besides the known hazards of the C. durissus sp. venom to animal health, this study was the first to show its effect also on male germ cells.
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