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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
Published on: September 14, 2013
Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool
Maureen T Taylor1,2, Janine McCready1,2, George Broukhanski3,4
1Division of Infectious Diseases, Department of Medicine, Michael Garron Hospital, Toronto, Ontario, Canada.
Abstract:
We evaluated the operating characteristics of 2 comparably trained dogs as a "point-of-care" diagnostic tool to detect toxin gene-positive Clostridium difficile. Although each dog could detect toxin gene-positive C difficile in stool specimens with sensitivities of 77.6 and 92.6 and specificities of 85.1 and 84.5, respectively, interrater reliability is only modest (Cohen's kappa 0.52), limiting widespread application.
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